DIABETIC MASTOPATHY
MORPHOLOGY
• Dense, keloid-like fibrosis with epithelioid myofibroblasts in stroma
• Periductal, perivascular, and perilobular lymphocytic infiltrates containing
predominantly B-cells
OTHER HIGH YIELD POINTS
• Fibroinflammatory breast lesion, which presents as a dense breast mass and is often bilateral
• Characteristically presents in premenopausal women with long-standing type 1 diabetes mellitus and can be recurrent
• It can be seen with other autoimmune disorders (Grave’s, Hashimoto, Pernicious anemia, SLE, RA, etc.) and in men
• IHC: CD20 (+) B-Cells
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