MORPHOLOGY
• A haphazard proliferation of small, round, uniform, tubular glands composed of a single layer of epithelium (without associated myoepithelial cells) that have bland nuclei and amphophilic cytoplasm
• Luminal spaces are open and often have eosinophilic colloid-like secretion
OTHER HIGH YIELD POINTS
• About 25% of cases are associated with invasive carcinoma
• Hypothesized to be non-obligate precursor of basal-type breast cancer
• IHC: (+) Cytokeratin, s100; (-)for ER, PR, HER2, and myoepithelial markers
• Molecular findings include copy number alterations, TP53 mutations, PIK3CA, and BRCA1 mutations
Image: Haphazard proliferation of small, round, uniform, tubular glands composed of a single layer of epithelium (without associated myoepithelial cells) that have bland nuclei and amphophilic cytoplasm. Luminal spaces have eosinophilic colloid-like secretion.
Path Presenter Whole Slide Image:
Comments